Invented by: |
Ramesh Narayanan Cordova, TN
Duane D. Miller Collierville, TN
Thamarai Ponnusamy Memphis, TN
Dong-Jin Hwang Arlington, TN
Jayaprakash Pagadala Boca Raton, FL
Charles B. Duke Memphis, TN
Christopher C. Coss Upper Arlington, OH
James T. Dalton Ann Arbor, MI
Yali He Germantown, TN Applicant: Name City State Country Type GTx, Inc. University of Tennessee Research Foundation Memphis Knoxville TN TN US US
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Examined by: | Seaman; D Margaret M |
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject. |