Luggage having an integrated compression system where at least one vacuum compression bag is provided and secured within the interior space of the luggage. The bag can be compressed by an attached self-contained vacuum assembly removably secured within the luggage, preferably between the handle tube guides. The air outlet opening of the bag can be provided with a valve or coupling for securement to the air entry inlet of the vacuum assembly. The bag can also be removably secured to other areas within the interior of the luggage. An air outlet of the vacuum assembly can be provided with a valve or coupling for securement to an opening in the back wall of the luggage. Alternatively, the valve or coupling can be provided in the back wall opening. Air removed from the compression bag by the vacuum assembly is expelled through the back wall opening, without the use of any exposed hoses. This allows the oversized compression bag as compared to the size of the luggage and the contents stored within the bag to be able to safely contained within the fully closed luggage. The battery for powering the vacuum assembly can be removable while the luggage is fully closed and can also be used to charge other electronic devices.