The manufacture of polyetherquinoxalines may be accomplished by polymerization of quinoxaline and related monomers with a bisphenol under aromatic nucleophilic substitution reaction conditions. A method of manufacture includes contacting a substituted or unsubstituted quinoxaline having replaceable groups at the 2,3 positions with a bisphenol or a bisphenol derivative under aromatic nucleophilic substitution reaction conditions. The resulting polyetherquinoxalines contain quinoxaline groups joined by ether linkages at the 2 and 3 positions of the quinoxaline groups. In one example, the polyetherquinoxaline has a formula represented as ##STR00001## wherein "n" is an integer from 1 to 10000, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 are independently hydrogen, methyl, CF.sub.3, tert-butyl, benzoyl, benzenesulfonyl, a sulfonic acid salt, an aliphatic group, an alicyclic group, or an aryl group, and Ar is an aromatic radical. These melt-processable polyetherquinoxalines can be prepared under relatively mild conditions, have excellent thermal and mechanical properties, and are organo-soluble, transparent and colorless thermoplastics.