A modular sealing and seal activation system for use with a combination of a panel and a frame includes a plurality of sealing system modules and a seal activation system. The plurality of sealing system modules are disposed within the frame and are removably attachable to the frame. Each of the sealing system modules is movable between a disengaged configuration and an engaged configuration. The seal activation system is connected to at least one of the sealing system modules, and the seal activation system moves the at least one of the sealing system modules between the engaged configuration and the disengaged configuration. The plurality of sealing system modules are substantially, identically sized, and the seals, in combination, are formed substantially, completely around the panel.