A combination sealing system and seal activation system for use with a combination of a panel and a frame includes a first sealing system and a first seal activation system for activating the first sealing system. The first sealing system is positioned within the frame, and the first seal activation system is positioned within panel and includes a movable member configured to engage the first sealing system. The first sealing system includes a movable member. The movable member of the first sealing system is caused to move towards the panel to form a seal between the panel and the frame when the movable member of the first seal activation system moves towards the frame.