A dispenser system for flowable material includes several interchangeable cartridge assemblies for retaining flowable material, each cartridge assembly including a dispensing piston sealingly and slidably retained within a cylinder, the cylinder having a distal cylinder dispensing end to which a material passing attachment can be sealingly mounted and having a proximal cylinder mounting end, and the piston including a piston head for creating the slidable seal within the cylinder and a piston drive mechanism connected to the piston; a drive structure for engaging and mounting the cartridge assembly and for progressively driving the flowable material out of the cartridge assembly and onto a target surface, the drive structure including a cartridge assembly engagement structure and having a piston drive mechanism which drivably and releasibly engages the piston drive mechanism upon fitting the cylinder to the engagement structure.