A method for minimizing undesired signal coupling from digital interface between peripherals is presented. The method includes transmitting over the interface first and second signals having a parameter .zeta..sub.k set by a dynamic sequencer respectively to a first and second value .alpha..sub.1 and .alpha..sub.2, receiving the first and second signal and generating a first and second interference metric respectively for the first and second signal. The first and second interference metrics are correlated to generate a final parameter value .alpha..sub.f, and a transmitter is then configured to transmit a third signal over the interface with the final parameter value .alpha..sub.f.