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Biologically active antibodies recognizing a cell surface molecule selectively expressed on living mouse natural type one (I) interferon producing cells

Invented by:

Amanda L. Blasius
Boca Raton, FL

Marco Colonna
St. Louis, MO

Marina Cella
St. Louis, MO Applicant: Name City State Country Blasius

Originally Assigned to:

Amanda L. Blasius
Boca Raton, FL
[Now assigned to . . .]

Marco Colonna
St. Louis, MO
[Now assigned to . . .]

Marina Cella
St. Louis, MO Applicant: Name City State Country Blasius
[Now assigned to . . .]

Issued:

2013-03-05

Filed:

2004-11-23

Application No:

11570118

Examined by:

Saoud; Christine J

An isolated and characterized monoclonal antibody ("440c") prepared by immunizing Wistar/CRL rats subcutaneously with purified rat bone marrow IPC, fusing popliteal lymph nodes of the rats with SP2/0 myeloma spleen cells and differentially selecting for hybridome supernatants that successfully stain bone marrow derived IPC and fractions thereof using CD11c+ spleen cells and, differentially selecting for hybridoma supernatants from the CD11c+ spleen cells that successfully stain only CD 11 c+/Ly6c+/CD 11 b-/B220+ splenocytes to provide the monoclonal antibody.

[pdf] U.S. Pat. No. 8,389,694

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