A computer-implemented method of generating future medical episodic simulations is provided. The method includes generating a personal wellness lifestyle signature for an individual based upon pre-selected data pertinent to wellness of the individual. Additionally, the method includes comparing the personal wellness lifestyle signature of the individual with at least one personal wellness lifestyle signature of at least one other individual determined to have at least one wellness characteristic similar to a corresponding wellness characteristic of the individual. The method further includes predicting at least one future medical episode corresponding to the individual based upon the comparison. A computer-based system for generating future medical episodic simulations is also provided. The system includes one or more one processors having logic circuitry for processing data. The system also includes a signature-generating module configured to execute on the at least one processor for generating a personal wellness lifestyle signature for an individual based upon pre-selected data pertinent to wellness of the individual. Additionally, the system includes a comparing module configured to execute on the at least one processor for comparing the personal wellness lifestyle signature of the individual with at least one personal wellness lifestyle signature of at least one other individual determined to have at least one wellness characteristic similar to a corresponding wellness characteristic of the individual. The system further includes an episode-predicting module configured to execute on the at least one processor for predicting at least one future medical episode corresponding to the individual based upon the comparison.