A deep-water power generation system includes an initially evacuated enclosure having walls of suitable strength or reinforcement for maintaining its structural integrity thereof in deep-water pressures; a power axle extending through the enclosure from a north pole to below a south pole of the enclosure; preferably concave blades of a turbine secured upon a support frame secured to the power axle in a latitudinal plane of the enclosure; and inlet ports within the enclosure positioned at the latitudinal plane of the blades of the turbine and receiving an inflow of ambient deep water against the blades, in which a couple effect of force from the fluid flow induces rotation of the blades and of the power axle secured to the frame. A thrust deck is rigidly secured, within the enclosure, to the power axle above the turbine and to a generator secured upon the thrust deck. At the south pole of the enclosure, water is expelled into a high-pressure injection well descending to a geological level of a saline aquifer or discharged from a water chamber at the south pole and into a main water body under pressure provided to a discharge chamber in excess of the ambient deep-water pressure.